A vaccine that works


I confess I was writing a summary of my articles on SARS-CoV-2 and it was not going well. Maybe I will start from scratch, but in the meantime, my colleagues Kelly Kandra and Elias Olsen and I have made a video. (It is a little stiff, but we will get better at it). When this infection started, there was one scientific paper in The Lancet, the British medical journal and the SARS-Cov-2 sequence that arrived at the NIH on January 10, 2020. The stories of the first scientists who discovered the disease and sequenced the virus are heroic because doing science in an authoritarian society can be scary. The intense effort continued in labs and hospitals around the world. There are now tens of thousands of papers and we know a lot about the biology of the Coronaviruses and how to confront them.
Most important, we have several vaccines and more specialized ones on the way. There have been few adverse effects, but people wisely have questions. One is about side effects. So far there have been very few. Second shots of the Moderna and Pfizer vaccines sometimes cause a day of slight fever. So do other vaccines; it’s a small price to pay.
What about efficacy? No person, even old people who got properly vaccinated died of Covid-19. The clinical trials were thorough and convincing. They involved 30,000 people in the Phase 3 trials. In fairness, clinical trials cannot pick up an event that occurs once in a million vaccinated people.
Are these vaccines safe if they were made so quickly? Yes. With older vaccines we did not know why or how the virus was attenuated; it just was. Scientists had to passage the measles, mumps and rubella viruses through cells and animals until they found a variant that could provoke an immune response without hurting an animal or a person. That takes years.
Poliovirus has about 6000 subunits called ribonucleotides in its genome. In the attenuated Sabin vaccine, only a few of these were altered. Prof. Vincent Racaniello at Columbia discovered the small number of changes after sequencing DNA became possible. For years the world used that vaccine without knowing the small number of changes in the virus. With mRNA technology scientists deleted all genes except the famous Spike protein, so no viruses are made. The current vaccines deal with all current variants of the Spike protein. Many new vaccines will be made using this technology, including to Zika, Ebola, Respiratory Syncytial Virus and others. mRNA is not the only new and promising technology.
Let us know if the video is useful and the scientific subjects people want to read about, assuming that Covid-19 cases continue to decline. My thanks to Elias Olsen and Kelly Kandra.
I will write a longer article or teach a course, and there will be more videos, but for the moment, like many people, we are going to see our grandchildren.
Rich Kessin is Emeritus Professor of Pathology and Cell Biology at the Columbia University Irving Medical Center. He and Galene Kessin live in Norfolk, Conn.
Email: Richard.Kessin@gmail.com
Website: Richardkessin.com (contains earlier columns and other writings on science). A work in progress.
The Lakeville Journal: /body-scientific
The Berkshire Edge: https://theberkshireedge.com/the-body-scientific--19-vaccines
“Once Upon a Time in America” features ten portraits by artist Katro Storm.
The Kearcher-Monsell Gallery at Housatonic Valley Regional High School in Falls Village is once again host to a wonderful student-curated exhibition. “Once Upon a Time in America,” ten portraits by New Haven artist Katro Storm, opened on Nov. 20 and will run through the end of the year.
“This is our first show of the year,” said senior student Alex Wilbur, the current head intern who oversees the student-run gallery. “I inherited the position last year from Elinor Wolgemuth. It’s been really amazing to take charge and see this through.”
Part of what became a capstone project for Wolgemuth, she left behind a comprehensive guide to help future student interns manage the gallery effectively. “Everything from who we should contact, the steps to take for everything, our donors,” Wilbur said. “It’s really extensive and it’s been a huge help.”
Art teacher Lilly Rand Barnett first met Storm a few years ago through his ICEHOUSE Project Space exhibition in Sharon, “Will It Grow in Sharon?” in which he planted cotton and tobacco as part of an exploration of ancestral heritage.
“And the plants did grow,” said Barnett. She asked Storm if her students could use them, and the resulting work became a project for that year’s Troutbeck Symposium, the annual student-led event in Amenia that uncovers little-known or under-told histories of marginalized communities, particularly BIPOC histories.
Last spring, Rand emailed to ask if Storm would consider a solo show at HVRHS. He agreed.
And just a few weeks ago, he arrived — paints, brushes and canvases in tow.
“When Katro came to start hanging everything, he took up a mini art residency in Ms. Rand’s room,” Wilbur said. “All her students were able to see his process and talk to him. It was great working with him.”
Perhaps more unexpected was his openness. “He really trusted us as curators and visionaries,” Wilbur said. “He said, ‘Do with it what you will.’”

Storm’s artistic training began at New Haven’s Educational Center for the Arts. His talent earned him a full scholarship to the Arts Institute of Boston, then Boston’s Museum School, where he painted seven oversized portraits of influential Black figures — in seven days — for his final project. Those works became the backbone of his early exhibitions, including at Howard University’s National Council for the Arts.
Storm has created several community murals like the 2009 READ Mural featuring local heroes, and several literacy and wellness murals at the Stetson Branch Library in New Haven. Today, he teaches and works, he said, “wherever I set up shop. Sometimes I go outside. Sometimes I’m on top of roofs. Wherever it is, I get the job done.”
His deep ties to education made a high school gallery an especially meaningful stop. “No one really knew who these people were except maybe John Lennon,” Storm said of the portraits in the show. “It’s really important for them to know James Baldwin and Shirley Chisholm. And now they do.”
The exhibition includes a wide list of subjects: James Baldwin, Shirley Chisholm, Redd Foxx, Jasper Johns, Marilyn Manson, William F. Buckley, Harold Hunter, John Lennon, as well as two deeply personal works — a portrait of Tracy Sherrod (“She’s a friend of mine… She had an interesting hairdo”) and a tribute to his late friend Nes Rivera. “Most of the time I choose my subjects because there are things I want to see,” Storm said.
Storm’s paintings, which he describes as “full frontal figuratism,” rely on drips, tonal shifts, and what feels like emerging depth. His process moves quickly. “It depends on how fast it needs to get done,” he said. “Sometimes I like to take the long way up the mountain. Instead of doing an outline, I just start coloring, blocking things off with light and dark until it starts to take shape.”
He’s currently in a black-and-white phase. “Right now, I’m inspired by black and white, the way I can really get contrast and depth.”
Work happens on multiple canvases at once. “Sometimes I’ll have five paintings going on at one time because I go through different moods, and then there’s the way the light hits,” he said. “It’s kind of like cooking. You’ve got a couple things going at once, a couple things cooking, and you just try to reach that deadline.”
For Wilbur, who has studied studio arts “ever since I was really young” and recently applied early decision to Vassar, the experience has been transformative. For Storm — an artist who built an early career painting seven portraits in seven days and has turned New York’s subway corridors into a makeshift museum — it has been another chance to merge artmaking with education, and to pass a torch to a new generation of curators.
Le Petit Ranch offers animal-assisted therapy and learning programs for children and seniors in Sheffield.
Le Petit Ranch, a nonprofit offering animal-assisted therapy and learning programs, opened in April at 147 Bears Den Road in Sheffield. Founded by Marjorie Borreda, the center provides programs for children, families and seniors using miniature horses, rescued greyhounds, guinea pigs and chickens.
Borreda, who moved to Sheffield with her husband, Mitch Moulton, and their two children to be closer to his family, has transformed her longtime love of animals into her career. She completed certifications in animal-assisted therapy and coaching in 2023, along with coursework in psychiatry, psychology, literacy and veterinary skills.
Le Petit Ranch operates out of two small structures next to the family’s home: a one-room schoolhouse for animal-assisted learning sessions and a compact stable for the three miniature horses, Mini Mac, Rocket and Miso. Other partner animals include two rescued Spanish greyhounds, Yayi and Ronya; four guinea pigs and a flock of chickens.
Borreda offers programs at the Scoville Library in Salisbury, at Salisbury Central School and surrounding towns to support those who benefit from non-traditional learning environments.
“Animal-assisted education partners with animals to support learning in math, reading, writing, language and physical education,” she said. One activity, equimotricité, has children lead miniature horses through obstacle courses to build autonomy, confidence and motor skills.

She also brings her greyhounds into schools for a “min vet clinic,” a workshop that turns lessons on dog biology and measuring skills into hands-on, movement-based learning. A separate dog-bite prevention workshop teaches children how to read canine body language and respond calmly.
Parents and teachers report strong results. More than 90% of parents observed greater empathy, reduced anxiety, increased self-confidence and improved communication and cooperation in their children, and every parent said animal-assisted education made school more enjoyable — with many calling it “the highlight of their week.”

Le Petit Ranch also serves seniors, including nursing home residents experiencing depression, social withdrawal or reduced physical activity. Weekly small-group sessions with animals can stimulate cognitive function and improve motor skills, balance and mobility.
Families can visit Le Petit Ranch for animal- assisted afterschool sessions, Frech immersion or family walks. She also offers programs for schools, libraries, community centers, churches, senior centers and nursing homes.
For more information, email info@lepetitranch.com, visit lepetitranch.com, follow @le.petit.ranch on Instagram or call 413-200-8081.