Measles Again! But Why?

Measles Again! But Why?

A case of measles with spots appearing on the face.

Provided

The measles vaccine was licensed in 1963. It is a live attenuated virus vaccine that provides lifelong protection with few side effects. It does not cause autism. The virus is extraordinarily contagious. The measles vaccine is usually given with mumps and rubella vaccines, and often with the chicken pox vaccine. With earlier vaccines for whooping cough, tetanus, and diphtheria, and in the 1950’s, polio, life for children and parents became less fearful.

But let’s go back to 1963, when every child in the United States and across the world got measles. It caused them true misery. There were about 600,000 cases in children in 1963.

People my age (old) will sometimes say, “I had measles, and it was no big deal, it was uncomfortable, and I had a fever, and all those spots scared my Mom, but I got over it.” This sort of extrapolation is dangerous because humans are not genetically identical, and our immune systems vary—for 20% children and their parents, measles was a very big deal; they had complications, usually encephalitis, an infection of the brain, pneumonia, or ear infections.

In 1963, about 120,000 children were hospitalized in the U.S., and about 400 died. Other estimates are higher.

Measles is a respiratory disease; we inhale virus particles, and they infect cells of the trachea and upper lung. They go on to infect immune cells, which carry the virus to all parts of the body, including the skin where the spots appear. Usually, the spots start in the scalp and then appear on the face, the trunk, and extremities in that order. It has an incubation period of weeks and takes some time to get over. Measles is common in other parts of the world; it is still a killer in Africa and Asia.

The measles virus is made of RNA, which differs slightly from DNA. Many other nasty viruses, including SARS-CoV-2, Ebola, and polio are made of RNA. Measles virus is about half the size of SARS-CoV-2, and only has six genes. The human genome is 3.2 billion nucleotides, a million times more that this virus. The virus is small, but potent. One of its powers is to defeat the defenses of an unvaccinated host.

We have two immune systems: innate and adaptive. The much older innate system is the first point of contact with a virus, and it has many tools to slow an infection, but only if it recognizes the virus RNA, its genetic material. The measles virus has incorporated into its tiny genome instructions to make an enzyme, or catalyst, called adenosine deaminase, which removes a nitrogen atom and a couple of hydrogens from adenosine components of the virus. That makes the virus invisible to the innate immune system but does not affect the ability of the virus to make thousands of copies of itself. The innate immune system has many tools to fight infections, but with measles the virus hides in plain sight.

Imagine an unvaccinated child with a case of measles. The child survives, but how long does impairment of the innate immune system last? Several years, it seems. The measles virus affects the antibodies that react against other diseases that the child has already survived.

Without that protection, old but latent infections—say hepatitis, can be reawakened and new virus infections become more dangerous. What measles research tells us goes beyond measles.

The measles virus evolved (perhaps a thousand years ago) from a cattle virus called Rinderpest, to which it remains similar. Rinderpest virus has been eliminated from cattle through vaccination. (The only other virus to be eliminated was smallpox). In 2000, the United States was sufficiently vaccinated that no cases of measles were recorded. The excellence of the vaccine and experience with Rinderpest led to the idea of eliminating the measles virus, but a decline in vaccine acceptance after a false autism scare, ended that hope. We now have periodic outbreaks of measles, usually from isolated communities. These cases are indicators that the public health system has deteriorated, often for ideological reasons, as is now the case in Florida. Think of measles infections as a harbinger, or to use a cliché, a canary in a coal mine.

The Florida health authorities are deluded. If for measles, what else? Perhaps mumps, rubella, and chickenpox.

Richard Kessin, PhD is Emeritus Professor of Pathology and Cell Biology at the Columbia University Irving Medical Center. Email: Richard.Kessin@gmail.com.

The views expressed here are not necessarily those of The Lakeville Journal and The Journal does not support or oppose candidates for public office.

Latest News

Remembering George and Anne Phillips’ Edgewood restaurant in Amenia

The Edgewood Restaurant, a beloved Amenia roadside restaurant run by George and Anne Phillips, pictured during its peak years in the 1950s and ’60s.

Provided

With the recent death of George Phillips at 100, locals are remembering the Edgewood Restaurant, the Amenia supper club he and his wife, Anne Phillips, owned and operated together for more than two decades.

At the Edgewood, there were Delmonico steaks George carved in the basement, lobster tails from an infrared cooker, local trout from the stream outside the door, and a folded paper cup of butter, with heaping bowls of family-style potatoes and vegetables, plus a shot glass of crème de menthe to calm the stomach when the modest check arrived after dessert.

Keep ReadingShow less
Artist Alissa DeGregorio brings her work to Roxbury and New Milford

Alissa DeGregorio, a New Milford -based artist and designer, has pieces on display at Mine Hill Distillery.

Agnes Fohn
When I’m designing a book, I’m also the bridge between artist and author, the final step that pulls everything together.
— Alissa DeGregorio

A visit to Alissa DeGregorio Art, the website of the artist and designer, reveals the multiple talents she possesses.

Tabs for design, commissions, print club, and classes still reveal only part of her work.On the design page are examples of graphic and book design, including book covers illustrated by DeGregorio, along with samples of licensed products such as coloring pages and lunch boxes, and examples of prop design she has done for film.

Keep ReadingShow less

Agnes Martin at Dia:Beacon

Agnes Martin at Dia:Beacon

Minimalist works by Agnes Martin on display at Dia:Beacon.

D.H. Callahan

At Dia:Beacon, simplicity commands attention.

On Saturday, April 4, the venerated modern art museum — located at 3 Beekman St. in Beacon, NY — opened an exhibition of works by the middle- to late-20th-century minimalist artist Agnes Martin.

Keep ReadingShow less
google preferred source

Want more of our stories on Google? Click here to make us a Preferred Source.

Falls Village exhibit honors life and work of Priscilla Belcher

Hunt Library in Falls Village will present a commemorative show of paintings and etchings by the late Priscilla Belcher of Falls Village.

Lydia Downs

Priscilla Belcher, a Canaan resident who was known for her community involvement and willingness to speak out, will be featured in a posthumous exhibition at the ArtWall at the Hunt Library from April 25 through May 15.

An opening reception will be held from 5 to 7 p.m. on April 25. The show will commemorate her life and work and will include watercolors and etchings. Belcher died in November 2025 at the age of 95.

Keep ReadingShow less
Crescendo’s 'Stepping Into Song' blends Jewish, Argentine traditions

The sounds of Argentine tango and Jewish folk traditions will collide in a rare cross-cultural performance April 25 and 26, when Berkshire’s Crescendo presents the choral program “Stepping Into Song.”

Christine Gevert, Crescendo’s founding artistic director, described the concert as “a world-class, diverse cultural experience” pairing “A Jewish Cantata” with Martin Palmeri’s “Misa a Buenos Aires.”

Keep ReadingShow less
Salisbury Rotary brings Derby race-day flair to Noble Horizons for community fundraiser
Salisbury Rotary Club President Bill Pond and his wife, Beth, dressed for the occasion during last year’s Kentucky Derby Social.
Provided

SALISBURY — As millions tune in to the Kentucky Derby at Churchill Downs on May 2, a spirited local tradition unfolds in Salisbury, where the pageantry, fashion and excitement of race day are recreated — with a community purpose.

For the past six years in the Community Room at Noble Horizons, all eyes turn to the big screen as the crowd settles in, drinks in hand and anticipation building. Women in elaborate Derby hats — bursting with oversized silk flowers, feathers and playful cutouts — mingle with men dressed for the occasion in crisp jackets and bow ties, fedoras and the occasional red rose on a lapel.

Keep ReadingShow less
google preferred source

Want more of our stories on Google? Click here to make us a Preferred Source.

google preferred source

Want more of our stories on Google? Click here to make us a Preferred Source.